Scientific Publications: Internationally Referred

Trainees and Staff Underlined

*authors equal senior authors

  1. Vine D, Hart R, Beilin L, Hickey M, Burrow S, Huan R-C, Proctor S. Mori T. ApoB48-Lipoproteins are Associated with Cardiometabolic Risk in Adolescents with and without Polycystic Ovary Syndrome (2020). J Endocrine Society (in press).
  2. Krysa J, Vine D, Beilin L, Burrow S, Huan R-C, Mori T, Proctor S. (2020). ApoB48-Remnant Lipoproteins Are Associated with Increased Cardiometabolic Risk in Adolescents. Atherosclerosis, 302:20-26. 
  3. Kupreeva M, Diane A, Lehner R, Watts R, Ghosh M, Proctor S, Vine DF. Metformin and Flutamide Differentially Modulate Insulin-Glucose, Lipid and Apo-B Lipoprotein Metabolism, and Reproductive-Endocrine Function in a PCOS-prone rodent model.Am J Physiol: Endocrinol and Metab. 2019;316 (1):E16-E33.
  4. Mangat R, Borthwick F, Haase T, Jacome-Sosa MM, Nelson R, Kontush A, Vine DF, Proctor SD.  Intestinal lymphatic HDL miR-223 is involved in HDL biogenesis that is impaired during insulin resistance and is restored with Niacin. The FASEB Journal, 2018;10: 12-29.
  5. Liu, Guangyu*; Huang, Weijuan; Babii, Oksana ; Gong, Xiaoyu; Tian, Zhigang; Yang, Jingqi; Wang, Yixiang; Jacobs, Rene L.; Donna, Vine; Lavasanifar, Afsaneh; Chen, Lingyun. (2018). Novel protein-lipid composite nanoparticles with inner aqueous compartment as delivery systems of hydrophilic nutraceutical compounds. Nanoscale. 10: 10629-40. 
  6. Lim DW, Diané A, Muto M, Vine DF, Nation PN, Wizzard PR, Sigalet DL, Bigam DL, Pencharz PB, Turner JM, Wales PW. Differential Effects on Intestinal Adaptation Following Exogenous Glucagon-Like Peptide 2 Therapy With and Without Enteral Nutrition in Neonatal Short Bowel Syndrome. JPEN J Parenter Enteral Nutr. 2017 Feb;41(2):156-170.  PMID: 27660290
  7. Vine DF, Wang F, Jetha M, Ball G, Proctor SD. Impaired ApoB-Lipoprotein and Triglyceride Metabolism in Obese Adolescents with Polycystic Ovary Syndrome. Journal Clinical Endocrinology and Metabolism. 2017 Mar 1;102(3):970-982. PMID:27997268 (IF=6.2) 
  8. Jacqueline KA, Proctor SD, Vine DF. Metabolic and Dietary Modulation of PCSK9; Effects on CardiometaboRisk Factors.  Journal of Nutrition. 2017 Apr;147(4):473-481. PMID:28179493.  (IF-4.145).  
  9. Ooi TC, Krysa J, Chaker S, Abujrad H, Mayne J, Henry K, Cousins M, Raymond A, Favreau C, Taljaard M, Chrétien M, Mbikay M, Proctor SD, Vine DF. The Effect of PCSK9 Loss-of-Function Variants on the Postprandial Lipid and ApoB-Lipoprotein Response. J Clin Endocrinol Metab. 2017 Sep 1;102(9):3452-3460. PMID: 28673045. (IF=5.455).   
  10. Lim DW, Levesque CL, Vine DF, Muto M, Koepke JR, Nation PN, Wizzsard PR, Li J, Bigam DL, Brubaker PL, Turner J. Synergy of glucagon-like peptide-2 and epidermal growth factor co-administration on intestinal adaptation in neonatal piglets with short bowel syndrome.  American Journal of Physiology-Gastrointestinal and Liver Physiology. 2017 Apr 1;312(4):G390-G404.
  11. Lavallee CM, Wizzard PR, Lansing M, Vine DF, Nation PN. Surgical Anatomy Does Not Affect the Progression of Intestinal Failure–Associated Liver Disease in Neonatal Piglets. J Parenter Enteral Nutr.2017;1: 10-25. (IF=3.15).
  12. Jacome-Sosa MM, Vacca C, Mangat R, Diane A, Nelson RC, Reaney MJ, Shen J, Curtis JM, Vine DF, Field C, Igarashi M, Piomelli D, Banni S and Proctor SD. Vaccenic acid suppresses intestinal inflammation by increasing the endocannabinoid anandamide and non-cannabinoid signaling molecules in a rat model of the metabolic syndrome. Journal of Lipid Research. 2016 Apr;57(4):638-49. PMID: 26891736 
  13. Diane A, Borthwick F, Mapiye C, Vahamani P, David RC, Vine DF, Dugan M, Proctor S.(2015). Beef fat enriched with PUFA biohydregenation products improves insulin sensitivity in insulin resistant JCR:LA-cp rats. Lipids. 2016 Jul;51(7):821-31.  PMID:  27072368
  14. Jacome-Sosa MM, Vacca C, Diane A, Reaney MJ, Shen J, Curtis J, Vine DF, Field C, Banni S and Proctor SD. Trans-11 vaccenic acid exerts tissue specific regulation of endocannabinoids in a rodent model of metabolic syndrome (the JCR:LA-cp rat). Journal of Lipid Research. 2016 Apr;57(4):638-49. PMID: 26891736 
  15. Diane A, Borthwick F, Mapiye C, Vahamani P, David RC, Vine DF, Dugan M, Proctor S. Feeding beef fat enriched with polyunsaturated fatty acid biohydrogenation products improves insulin sensitivity in insulin resistant JCR:LA-cp rats. Lipids.  2016 Jul;51(7):821-31.  PMID:  27072368
  16. Diane A, Borthwick F, Wu S, Lee J, Brown P, Dickinson TA, Croft KD,  Vine DF,  Proctor SD.   Hypolipidemic and cardioprotective benefits of a novel fireberry hawthorn fruit extract in the JCR:LA-cp rodent model of dyslipidemia and cardiac dysfunction.  Food and Function.  2016 Sep 14;7(9):3943-52. 
  17. Diane A, Pierce D, Kelly S, Sokolik S, Borthwick F, Jacome-Sosa M, Mangat R, Pradillo MJ, McRae AS, Ruth MR, Field CJ, Hutcheon R, Rocic P, Russell JC, Vine DF, Proctor SD.  Mechanisms of Co-Morbidities Associate with The Metabolic Syndrome:  Insights From The JCR:LA-cp Corpulent Rat Strain.  Frontiers.  2016 Oct. 10;3:44.  PMID:  27777929.  
  18. Zhang J, Field CJ, Vine DF, Chen L.  Intestinal Uptake and Transport of Vitamin B12-loaded Soy Protein Nanoparticles. Pharmaceutical Research.  2015 April;4(32)1288-1303.
  19. da Silva RP, Karen B Kelly KB; Lewis E, Leonard KA, Goruk S, Curtis JM, Vine DF, Proctor SD, Field CJ and Jacobs R. Choline deficiency impairs intestinal lipid metabolism in the lactating rat. Journal of Nutritional Biochemistry. 2015 Oct;26(10):1077-1083. PMID: 26092371.
  20. Diane A, Pierce W, Mangat R, Borthwick F, Nelson R, Russell J, Heth C, Jacobs R, Vine DF, and Proctor SD.  Differential Expression of Hypothalamic Metabolic and Inflammatory Genes in Response to Short-Term Calorie Restriction in Juvenile Obese- and Lean-prone JCR Rats.  Nutrition & Diabetes.  2015 Aug 24;5:e178. Open Access. PMID: 26302065. 
  21. Diane A, Kupreeva M, Borthwick F, Proctor SD, Pierce WD, Vine DF.  Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model.  J Endocrinol. 2015 Sep;226(3):193-206.  PMID: 26187902
  22. Borthwick F, Mangat R, Warnakula S, Jacome-Sosa M, Vine DF and Proctor SD. Simvastatin treatment upregulates intestinal lipid secretion pathways in a rodent model of the metabolic syndrome. Atherosclerosis. 2014 232; pp. 141-148, PMID: 24401228 (IF=3.97)
  23. Rajabi AA, Castro GS, da Silva RP, Nelson RC, Vannucchi H, Vine DF, Proctor SD, Field CJ, Curtis JM, Jacobs RL. Choline Supplementation Protects Against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet. Journal of Nutrition (Biochemistry). Journal of Nutrition. 2014 Mar;144(3):252-7. PMID: 24368431 (IF=4.59)
  24. Diane A, Vine DF, Russell JC,  Heth CD, Pierce WD, and Proctor SD. Interrelationship of CB1R and OBR pathways in regulation of metabolic, neuroendocrine and behavioral responses to food restriction and voluntary wheel running. J. Applied Physiology. 2014 Jun 15;117(2):97-104. PMID: 24903921. (IF=3.4)
  25. Vine DF, Wang F, Jetha MM, Proctor SD, Ball G.  Elevated Non-Fasting and Fasting ApoB-Lipoprotein Metabolism in Obese Adolescents with PCOS and Exacerbated Cardiovascular Disease Risk.  Endocrine Reviews. 2014 Jun 22;35(3):OR15.  
  26. Leblanc S, Battista MC, Noll C, Hallberg A, Gallo-Payet N, Carpentier AC, Vine DF, Baillargeon JP.(2014). Angiotensin II Type 2 Receptor Stimulation Improves Fatty Acid Ovarian Uptake and Hyperandrogenemia in an Obese Rat Model of Polycystic Ovary Syndrome.  Endocrinology. 155(9): 3684-93.
  27. Diane A, Pierce WD, Russell JC, Heth CD, Vine DF, Richard D, Proctor SD. Down regulation of hypothalamic pro-opiomelanocortin (POMC) expression after weaning is associated with hyperphagia- induced obesity in JCR rats over-expressing neuropeptide Y.  Br. J. Nutrition. 2013 Oct 7:1-9. PMID: 24094067.
  28. Mager DR, Mazurak V, Rodrigues-Dimitrescu C, Vine DF, Jetha M, Ball G, Yap J.  A meal high in saturated fat evokes postprandial dyslipidemia, hyperinsulinemia, and altered lipoprotein expression in obese children with and without nonalcoholic fatty liver disease.  Journal of Parenteral and Enteral Nutrition.  2013 Jul;37(4):517-28. PMID:  23223552.
  29. Diane A, Vine DF, Heth CD, Russell JC, Proctor SD, Pierce WD. Prior caloric restriction increases survival of pre-pubertal obese- and PCOS-prone rats exposed to a challenge of time-limited feeding and physical activity.  Journal of Applied Physiology. 2013 May;114(9):1158-64. PMID: 23449943
  30. Wang Y, Pendlebury C, Nzekwu MMU, Maximova K, Vine DF, Jetha MM, Ball GDC and Proctor SD. Elevated remnant lipoproteins may increase subclinical CVD risk in obese pre-pubertal children: A Canadian case control study.  Pediatr Obes. 2013 Oct;8(5):376-84. PMID: 23239597
  31. Wang Y, Jacome-Sosa M, Ruth MR, Goruk SD, Shen J, Reaney MJ, Scott SL, Dugan MER, Anderson HD, Field CJ, Proctor SD and Vine D.  The intestinal bioavailability of vaccenic acid and activation of peroxisome proliferator-activated receptor α and -γ rodent model of dyslipidemia and the metabolic syndrome. Molecular Nutrition and Food Research.  2012 Aug;56(8)1234-46.  (IF=4.3)
  32. Shi D and Vine DF.  Animal models of polycystic ovary syndrome:  a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk.  Reproductive Biology.  2012 Jul;98(1):185-93.   
  33. Vine DF, Bakovic M. Mechanisms of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) deficient mice.  Journal of Lipid Research.  2012 Sep;53(9):1811-22. 
  34. Mangat R, Warnakula S, Borthwick F, Hassanali Z, Uwiera R, Russell JC, Cheeseman CI, Vine DF and Proctor SD. Arterial retention of remnant lipoproteins ex-vivo is increased during insulin resistance due to increased arterial biglycan and production of cholesterol-rich atherogenic particles, that can be improved by ezetimibe in the JCR:LA-cp rat. Journal of the American Heart Association.  2012;1(5):e003434 doi: 10.1161/JAHA.112.003434
  35. Mangat R, Vine DF, Forbes JM, Cooper ME, Mamo JCL and Proctor SD.  Increased risk of cardiovascular disease in type 1 diabetes: arterial exposure to remnant lipoproteins leads to enhanced deposition of cholesterol and binding to glycated extracellular matrix proteoglycans.  Diabetic Medicine.  2011 Jan;28(1):61-72
  36. Lu J, Borthwick F, Hassanali Z, Wang Y, Mangat R, Shi D, Jaeschke A, Russell J, Field CJ, Proctor SD and Vine DF.  Chronic dietary n-3 PUFA intervention improves dyslipidemia and subsequent cardiovascular complications in the JCR:LA-cp rat model of the metabolic syndrome.  British Journal of Nutrition (2011), volume 105, issue 11, pp. 1572-1582 (IF=3.4).
  37. Ruth MR, Wang Y, Yu HM, Goruk S, Reaney MJ, Proctor SD,  Vine DF,  and Field CJ.  Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats.  Nutrients Journal.  2010.  Feb;2(2):181-97.
  38. Hassanali Z, Ametaj B, Field CJ, Vine DF and Proctor SD. Dietary supplementation with n-3 polyunsaturated fatty acids reduces weight gain and improves post-prandial lipemia and the associated inflammatory response in the obese JCR:LA-cp rodent. Diabetes Obesity and Metabolism.  2010.  Volume 12, Issue 2, Pages 139 – 147.  (IF=4.2).
  39. Mangat R, Warnakula S, Wang Y, Russell JC, Uwiera R and Vine DF and Proctor SD.  Model of Intestinal Chylomicron Over-production and Ezetimibe Treatment: Impact on the Retention of Cholesterol in Arterial Vessels.  Atherosclerosis Supplements.  2010 Jun;11(1):17-24.  
  40. Jacome-Sosa M, Lu J, Wang Y, Ruth MR, Wright DC, Reaney MJ, Shene J, Field CJ, Vine DF and Proctor SD. Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat.  Nutrition & Metabolism.  Nutr Metab (Lond). 2010 Jul 16;7:60.
  41. Wang Y, Jacome-Sosa M, Vine DF and Proctor SD.  Beneficial effects of vaccenic acid on postprandial lipid metabolism and dyslipidemia: Impact of natural trans-fats to improve CVD risk.  Lipid Technology. Vol. 22 No. 5, Pages 103-106. May 2010.
  42. Russell JC, Kelly SE, Diane A, Wang Y, Mangat R, Novak S, Vine DF*, Proctor SD*.  Rimonabant-mediated changes in intestinal lipid metabolism and improved vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome.  AJP Gastro and Liver Physiol.  2010 Aug;299(2):G507-16.
  43. Shi D, Dyck M, Uwiera R, Russell J, Proctor S, Vine DF (2009). A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic and Polycystic Ovary Syndrome. Endocrinology Vol. 150, No. 9 4425-4436, Sep 2009. (IF=5.2).
  44. Field CJ, Hosea-Blewett H, Proctor SD and Vine DF. Human health benefits of vaccenic acid. Applied Physiology, Nutrition and Metabolism. 2009.  Vol. 34, Number 5, 979-991.
  45. Russell JC, Kelly SE, Vine DF and Proctor SD. Irbesartan-mediated reduction of renal and cardiac damage in insulin resistant  JCR:LA-cp rats. British Journal of Pharmacology. 2009.  Vol. 158, Issue 6, Pages 1588-1596.  (IF=4.9)
  46. Wang Y, Lu J, Ruth MR, Goruk SD, Reaney M, Glimm D, Vine DF, Field CJ and Proctor SD. Trans-11 vaccenic acid reduces hepatic lipogenesis and chylomicron secretion in the JCR:LA-cp rat. Journal of Nutrition. Vol. 139, No.11, 2049-2054. Nov. 2009