• Li Ka Shing (LKS) Centre for Health Research Innovation

Mission Statement

We are interested in fundamental and translational aspects of lipid metabolism in nutrition-related chronic diseases. In particular, how dietary (intestinal) derived lipids and their metabolism contribute to, or alleviate pathways that cause cardiovascular etiology.

We are keen to appreciate how the etiology of early obesity, insulin resistance and Type 2 diabetes accelerates CVD complications and influence lipid homeostasis. Our dynamic and vibrant group fosters a supportive research environment for staff/trainees in order to build capacity and facilitate unique inter-disciplinary scientific training.

Our Recent Scientific Publications

  1. Araujo G, Marian Valencia L, Martin-Ozimek A, Soto Y, Proctor SD.  Atherosclerosis: from lipid-lowering and anti-inflammatory therapies to targeting arterial retention of ApoB-containing lipoproteins. Front. Immunol., Review Article.  08 June 2025, Volume 16.  doi.org/10.3389/fimmu.2025.1485801
  2. Wu E, Wilke M, Raggi P, Becher H, Windram J, Proctor S, Ghosh M, Cree M, Vine D. (2025). ApoB-Remnant-Cholesterol Dyslipidemia, Atherosclerotic Cardiovascular Disease and Cardiac Dysfunction is Exacerbated in Young High-Risk Women with Obesity and Polycystic Ovary Syndrome:a pilot study. Frontiers in Endocrinology: A Lifecourse Perspective on Polycystic Ovary Syndrome (PCOS): Bridging Gaps in Research and Practice (in press)
  3. Hu S, Lalonde-Bester S, Salem J, Koshy S, Vine D, Harrison TG, Yamamoto JM, Benham JL. Validity of administrative health data case definitions for identifying polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2025. Online ahead of print.  doi:10.1093/humrep/deaf094
  4. Braga Tibaes JR, Barreto Silva MI, Azarcoya-Barrera J, Blanco Cervantes P, Makarowski A, Mereu L, Richard C. Assessment of immune function in individuals without and with obesity and normoglycemia, glucose intolerance, or type 2 diabetes: primary findings of the NutrIMM study, a single-arm controlled feeding trial.  Am J Clin Nutr.  2025 June;121(6):1315-1327.  doi: 10.1016/j.ajcnut.2025.03.003
  5. Holdaway CM, Leonard KA, Nelson R, van der Veen J, Das C, Watts R, Clugston RD, Lehner R, Jacobs RL. Alterations in phosphatidylethanolamine metabolism impacts hepatocellular lipid storage, energy homeostasis, and proliferation.  Biochim Biophys Acta Mol Cell Biol Lipids.  2025 May;1870(4):159608.  doi: 10.1016/j.bbalip.2025.159608. Epub 2025 Mar 26.
  6. Sydora B, Wilke M, Ghoshh M, Vine D. (2025). The Impact of the Covid-19 Pandemic on Health and Health Care Experience in those living with Polycystic Ovary Syndrome. International Journal of Women’s Health. 2025 Feb 4:17:287-298.  doi: 10.2147/IJWH.S504439

 

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