Research / Dr. Spencer Proctor / Publications

Publications

Scientific Publications: Internationally Referred

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1)   Proctor SD and Mamo JCL Arterial fatty lesions have increased uptake of chylomicron remnants but not low density lipoprotein. Coronary Artery Disease. 1996; 7: 239-245. Accepted 2 Jan 1996. PMID: 8827411

2)   Proctor SD and Mamo JCL. Separation and Quantitation of Apolipoprotein B48 and other apolipoproteins by Dynamic Sieving Capillary Electrophoresis. Journal Lipid Research. 1997; (38): 410-414. PMID:9162759

3)   Mamo JCL, Yu KCW, Elsegood CL, Smith D, Vine DF, Gennat HC, Voevodin M. and Proctor SD. Is atherosclerosis exclusively a post-prandial phenomenon? Clinical and Experimental Pharmacology and Physiology. 1997; 24: 288-293. Accepted 9 Dec 1996. PMID:9131300

4)   Smith D, Proctor SD and Mamo JCL. A highly sensitive assay for quantitation of Apolipoprotein B48 using an antibody to human Apolipoprotein B and Enhanced Chemiluminescence. Annals of Clinical Biochemistry. 1997; 34: 185-189. PMID:9133254

5)  Proctor SD and Mamo JCL. Retention of fluorescent-labeled chylomicron-remnants within the intima of the arterial wall- Evidence that plaque cholesterol may be derived from postprandial lipoproteins. European Journal of Clinical Investigation. 1998; 28(6): 497-503. Accepted 19 Feb 1998.  PMID:9693943

6)  Mamo JC, Smith D and Proctor SD. Retention of chylomicron remnants by arterial tissue; importance of an efficient clearance mechanism from plasma. Atherosclerosis. 1998;141 (Supplement 1): S63-S69. PMID:9888645 

7)   Pal S, Elsegood C, Proctor SD and Mamo JCL.  Detection of LDL-receptor by ligand blotting with chylomicronremnants labeled with colloidal gold. Annals of Clinical Biochemistry. 2000; 37: 471-478. PMID:10902863

 8)   Proctor SD, Pabla CK and Mamo JCL Arterial intimal retention of pro-atherogenic lipoproteins in insulin deficient rabbits and rats. Atherosclerosis 2000(1999); 149(2): 315-322. Accepted 20 August 1999. PMID:10729381

 9)  Mamo JCL and Proctor SD. Coronary Artery Disease; which lipoprotein is the villain?  Today’s Life Science July/August 2002. Vol 14; Issue 4 Pg 30-33; Front Cover Feature.

10)  Proctor SD, Vine DF and Mamo JCL. Arterial retention of apolipoprotein B48 and B100-containing lipoproteins in atherogenesis. Current Opinion in Lipidology 2002 Vol. 13, Issue 5 Pg 461-470) Front Cover Feature. (IF=7.0) PMID:12352009

11)  Proctor SD and Mamo JCL. Intimal retention of cholesterol derived from apolipoprotein B100- and apolipoprotein B48-containing lipoproteins in carotid arteries of Watanabe Heritable Hyperlipidemic Rabbits. Arteriosclerosis, Thrombosis and Vascular Biology 2003, Accepted May 20 2003, Vol 23, Issue 9 Pg 1595-1600, Front Cover Feature. (IF=6.5) PMID:12842838

12) Proctor SD, Vine DF and Mamo JCL. Arterial permeability and efflux of apolipoprotein B containing lipoproteins assessed by in-situ perfusion and three-dimensional quantitative confocal microscopy. Arteriosclerosis, Thrombosis and Vascular Biology 2004; Accepted July 26, 2004 24(11): 2162-2167. (IF=6.8).  PMID:15345509 

13)  Proctor SD, Kelly S and Russell JC. A novel of arginine-silicate improves Micro- and Macrovascular Function and inhibits glomerular sclerosis in Insulin-Resistant JCR:LA-cp Rats. Diabetologia 2005. Apr; 48(9):1925-32. Epub 2005 Jul 1. (IF=5.7) PMID: 15991019

14)   Russell JC, Proctor SD, Kelly SE, Löhn M, Busch AE and Schäfer S. Insulin-Sensitising and Cardiovascular Effects of the Sodium-Hydrogen Exchange Inhibitor, Cariporide, in the JCR:LA-cp Rat and db/db Mouse. Journal of Cardiovascular Pharmacology. 2005 Dec; 46(6):746-753. (IF=1.6).  PMID:16306797

15)  Proctor SD, Dreher KL, Kelly SE and Russell JC. Hypersensitivity of Prediabetic JCR:LA-cp Rats to fine airborne Combustion particle-Induced Direct and Noradrenergic-Mediated Vascular Contraction. Toxicological Sciences 2006 Jan; 90(2):385-391. (IF=3.4).  PMID:16407093

16)  Russell JC and Proctor SD Small animal models of cardiovascular disease: Tools for study of roles of the metabolic syndrome, dyslipidemias and atherosclerosis. Review for Cardiovascular Pathology 2006:15;318-330.(IF=1.7). PMID:17113010

17)  Vine DF, Takechi R, Russell JC and Proctor SD. Impaired postprandial apolipoprotein-B48 metabolism in obese insulin-resistant JCR:LA-cp rat: Increased atherogenicity for the metabolic syndrome. Atherosclerosis 2007 190(2):282-90. EPub.2006 Apr. (IF=3.8)  PMID:16624317

18) Proctor SD, Kelly SE, Stanhope KL, Havel PJ, and Russell JC. Synergistic effects of conjugated linoleic acid and chromium picolinate improve vascular function and renal pathophysiology in the insulin-resistant JCR:LA-cp rat. Diabetes, Obesity and Metabolism. 9,(1): 87-95 2007  (IF=2.5).  PMID: 17199723

19)  Russell JC and Proctor SD.  Increased insulin sensitivity and reduced micro and macro vascular disease induced by 2-deoxy-D-glucose during metabolic syndrome in obese JCR:LA-cp rats. British Journal of Pharmacology 151(2):216-225 2007. Jan epub 20 March 2007 (IF=3.4). PMID:17375078

20)     Mangat R, Su J, Scott PG, Russell JC, Vine DF and Proctor SD. Chylomicron and apoB48 metabolism in the JCR:LA corpulent rat, a model for the metabolic syndrome. Biochemical Society Transactions 2007 Jun; 35(Pt 3):477-81.  (IF=3.1)  PMID:17511632

21) Nzekwu MMU, Jetha MM, Ball GDC, Beaulieu C and Proctor SD. Apolipoprotein B48: a novel marker of metabolic risk in overweight children? Biochemical Society Transactions 2007 Jun; 35(Pt 3):484-6.  (IF=3.1)  PMID:17511634

22)  Pierce D, Heth D, Owczarczyk J, Russell JC and Proctor SD. Overeating by Young Obesity-prone and Lean Rats caused by tastes Associated with Low Energy Foods. Obesity (Silver Spring). 2007 Aug; 15(8):1969-79. PMID:17712114

23)  Proctor SD, Kelly S, Vine DF and Russell JC. Metabolic effects of a novel silicate inositol complex of the nitric oxide precursor arginine in the obese insulin- resistant JCR:LA-cp rat. Metabolism 2007 Oct; 56(10):1318-25. PMID:17884439

24)  Proctor SD Trans fats, dyslipidemia and the metabolic syndrome: are we missing the cream? Can Nurse. 2007 Nov; 103(9):10. PMID:18095523

25)  Duez H, Lamarche B, Valéro R, Pavlic M, Proctor SD, Xiao C, Szeto L, Patterson BW and Lewis GF. Both intestinal and hepatic lipoprotein production are stimulated by an acute elevation of plasma free fatty acids in humans. Circulation 2008 May 6; 117(18):2369-76. (IF=11.2). PMID:18443237

26)  Russell JC, Proctor SD, Kelly SE and Brindley D. Pair feeding-mediated changes in metabolism: stress response and pathophysiology in insulin resistant, atherosclerosis-prone JCR:LA-cp rats. American Journal of Physiology: Endocrinology and Metabolism. 2008 June; 294(6):E1078-87.  PMID:18413677

27)  Proctor SD, Vine DF, Botham K, Mamo JCL and Cabezas MC.  Intestinal post-prandial chylomicrons: State of the Union between liver, gut and dyslipidemia? Future Lipidology 2008. 3(5), 473-480.

28)  Vine DF, Glimm DR, Proctor SD. Intestinal Lipid Transport and Chylomicron Production: Possible Links to Exacerbated Atherogenesis in a Rodent Model of the Metabolic Syndrome. Atherosclerosis Supplements, 2008 9:69-76. (IF=4.9).  PMID:18632312

29)  Wang Y, Lu J, Ruth MR, Goruk SD, Reaney M, Glimm D, Vine DF, Field CJ and Proctor SD (2008). Trans-11 vaccenic acid dietary supplementation induces hypolipidemic effects in an animal model of dyslipidemia and the metabolic syndrome. Journal of Nutrition. 2008 138(11):2117-22.  (IF=3.6).  PMID:18936207

30)     Ruth MR, Proctor SD and Field CJ. Feeding long chain (n-3) polyunsaturated fatty acids to obese leptin receptor deficient JCR:LA-cp rats modifies immune function and lipid raft fatty acid composition. British Journal of Nutrition 2009 May:101(9):1341-1350 (IF=2.34). PMID:19079834

31)  Ruth MR, Proctor SD and Field CJ. Effect of Feeding Fish Oil on mesenteric lymph node cytokine responses in obese leptin receptor-deficient JCR:LA-cp Rats. International Journal of Obesity 2009 33(1):96-103. (IF=3.56).PMID: 19048014

32)  Su JW, Lambert JE, Clandinin MT and Proctor SD. Impaired Postprandial metabolism of Apolipoprotein B48-Containing Remnant Particles in Normolipidemic Subjects with Brittle Type 1 Diabetes. Diabetes Care 2009 Vol 32 (2), DOI 10.2337/dc08-1573  (IF=7.8).  PMID: 19171731

33)  Blewett HJ, Gergung CA, Ruth MR, Proctor SD and Field CJ. Vaccenic acid favorably alters immune function in obese JCR:LA-cp rats. British Journal Nutrition. 2009 Aug;102(4):526-536. PMID: 19216829

34)  Su JW, Nzekwu MMU, Ball GDC, Proctor SD. Postprandial lipemia as an early predictor of cardiovascular complications in childhood obesity. Journal of Clinical Lipidology. Feb 8 2009, Vol.3, 78-84.  PMID: 21291796

35)     Su JW, Nzekwu MMU, Castro-Cabezas M, Redgrave TG, Proctor SD.   Methods to assess impaired post-prandial metabolism and the impact for early detection of cardiovascular disease risk.  European Journal of Clinical Investigation.  2009 Sep;39(9):741-54. (IF=2.7). PMID: 19563468

36)  Field CJ, Hosea-Blewett H, Proctor SD and Vine DF. Human health benefits of vaccenic acid. Applied Physiology, Nutrition and Metabolism. 2009. Vol. 34, Number 5, 979-991. PMID:  19935865

37)  Shi D, Dyck MK, Uwiera RR, Russell JC, Proctor SD, Vine DF. A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic Syndrome and Polycystic Ovary Syndrome. Endocrinology. Vol. 150, No. 9, 4425-4436, Sept. 2009.  (IF=5.2).  PMID:19470707

38)     Wang Y, Lu J, Ruth MR, Goruk SD, Reaney M, Glimm D, Vine DF, Field CJ and Proctor SD. Trans-11 vaccenic acid reduces hepatic lipogenesis and chylomicron secretion in the JCR:LA-cp rat. Journal of Nutrition. Vol. 139, No. 11, 2049-2054, Nov. 2009. (IF=4.0). PMID: 19759243

39)  Russell JC, Kelly SE, Vine DF and Proctor SD. Irbesartan-mediated reduction of renal and cardiac damage in insulin resistant JCR:LA-cp rats. British Journal of Pharmacology.  2009.  Vol. 158, Issue 6, Pages 1588-1596. (IF=4.9) PMID:  19814728

40)  Hassanali Z, Ametaj B, Field CJ, Proctor SD and Vine DF. Dietary Supplementation of n-3 PUFA reduces weight gain, and improves post-prandial lipemia and the associated inflammatory response in the obese JCR:LA-cp rat. Diabetes, Obesity and Metabolism.  Feb 2010.  Volume 12, Issue 2, Pages 139 – 147.  (IF=4.26)PMID:19917068

41) Pierce WD, Diane A, Heth CD, Russell JC, Proctor SD. Evolution and obesity: resistance of obese-prone rats to a challenge of food restriction and wheel running.  International Journal Obesity. 2010. Mar; 34(3):589-92.(IF=3.6) PMID:20065962

42)  Ruth MR, Wang Y, Yu HM, Goruk S, Reaney MJ, Proctor SD,  Vine DF,  and Catherine J Field.  Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats.  Nutrients.  2010. 2:181-197.

43)  Mangat R, Warnakula S, Wang Y, Russell JC, Uwiera R and Vine DF and Proctor SD. Model of Intestinal Chylomicron Over-production and Ezetimibe Treatment: Impact on the Retention of Cholesterol in Arterial Vessels.  Atherosclerosis Supplements.  2010 Jun;11(1):17-24.  PMID:  20471328

44)  Wang Y, Jacome-Sosa M, Vine DF and Proctor SD.  Beneficial effects of vaccenic acid on postprandial lipid metabolism and dyslipidemia: Impact of natural trans-fats to improve CVD risk.  Lipid Technology. Vol. 22 No. 5, Pages 103-106, May 2010.

45)   Jacobs RL, Zhao Y, P.Y. Koonen DPY, Sletten T, Su B, Lingrell S, Cao G, Peake DA, Kuo MS, Proctor SD,Kennedy BP, Dyck JRB, and Vance DE.  Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.  Journal of Biological Chemistry.  2010 Jul 16;285(29):22403-13.  PMID:  20452975

46)  Russell JC, Kelly SE, Diane A, Wang Y, Mangat R, Novak S, Vine DF*, Proctor SD*.  Rimonabant-mediated changes in intestinal lipid metabolism and improved vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome.  AJP Gastro and Liver Physiol. 2010 Aug;299(2):G507-16.  PMID:  20508159

47)  Jacome-Sosa M,  Lu J,  Wang Y,  Ruth MR, Wright DC, Reaney MJ, Shene J, Field CJ, Vine DF and Proctor SD.Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat.  Nutrition & Metabolism.  Nutr Metab (Lond). 2010 Jul 16;7:60.  PMID:  20633302

48)  Ussher JR, Koves TR, Cadete VJJ, Zhang L, Jaswal JS, Swyrd SP, Lopaschuk DG,  Proctor SD, Keung W,  Muoio DM, and Lopaschuk GD.  Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and restores whole body oxygen consumption.  Diabetes.  2010 Oct;59(10):2453-64.  PMID: 20522596



49) Gavin C, Sigal RJ, Cousins M, Menard ML, Atkinson M, Khandwala F, Kenny GP, Proctor SD and  Ooi TC.   Resistance exercise but not aerobic exercise lowers remnant-like lipoprotein particle cholesterol in type 2 diabetes: A randomized controlled trial.  Atherosclerosis 213 (2010) 552-557.  PMID:20870234 

50)
Mangat R, Vine DF, Forbes JM, Cooper ME, Mamo JCL and Proctor SD.  Increased risk of cardiovascular disease in type 1 diabetes: Increased arterial exposure to remnant lipoproteins leads to enhanced deposition of cholesterol and binding to glycated extracellular matrix proteoglycans.  Diabetic Medicine.  2011 Jan;28(1):61-72.  PMID: 21166847 

51) 
Christian F. Rueda-Clausen, Vernon W. Dolinsky, Jude S. Morton, Spencer D. Proctor, Jason R.B. Dyck & Sandra T. Davidge. Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome. Diabetes. 2011 Feb;60(2):507-16. (IF=8.5) PMID: 21270262 

52)
 Warnakula S, Hsieh J, Adeli K, Hussain MM, Tso P, Proctor SD.  New insights into how the intestine can regulate lipid homeostasis and impact vascular disease: frontiers for new pharmaceutical therapies to continue to lower cardiovascular risk.  The Canadian Journal of Cardiology.  27 (2011) 183-191. (IF=2.224) PMID: 21459267

53)  Jing Lu, Faye Borthwick, Zahra Hassanali, Ye Wang, Rabban Mangat, Megan Ruth, Danni Shi, Anja Jaeschke, James C Russell, Catherine J Field, Spencer D Proctor* and Donna F Vine*.  Chronic dietary n-3 PUFA intervention improves dyslipidemia and subsequent cardiovascular complications in the JCR:LA-cp rat model of the metabolic syndrome.  British Journal of Nutrition (2011), volume 105, issue 11, pp. 1572-1582. (IF=3.4) PMID:21276281 

54) Gebauer SK, Chardigny JM, Jakobsen MU, Benoit L, Lock A, Proctor SD and Baer DJ. Effects of ruminant trans fatty acids on cardiovascular disease and cancer: a comprehensive review of epidemiological, clinical, and mechanistic studies. Advances in Nutrition. 2011,Jul;(2):332-354. (open access). PMID: 22332075

55) Drake C, Boutin H, Jones MS, Denes A, McColl BW, Selvarajah JR, Hulme S, Georgiou RF, Hinz R, Gerhard A, Vail A, Prenant C, Julyan P, Maroy R, Brown G, Smigova A, Herholz K, Kassiou M, Crossman D, Francis S, Proctor SD, Russell JC, Hopkins SJ, Tyrrell PJ, Rothwell NJ, Allan SM. Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behavioural and Immunity. 2011; 25(6-4):1113-1122. (IF=5.0) PMID: 21356305

56) Wang Y, Jacome-Sosa M and Proctor SD. The role of ruminant trans fat as a potential nutraceutical in the prevention of cardiovascular disease. Food Research International. 2012;46(2):460–468. (IF=2.41)

57) Klop B, Proctor SD, Mamo JCL, Botham K, and Cabezas MC. Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases. International Journal of Vascular Medicine. 2012;2011(947417):1-11. (open access). PMID:21961070

58) Cabezas MC, Botham K, Mamo JCL, Proctor SD. Novel Aspects of Nonfasting Lipemia in relation to Vascular Biology. International Journal of Vascular Medicine. Int J Vasc Med. 2012;2012:419015. (open access). PMID:22548177

59) Diane A, Pierce WD, Heth CD, Russell JC, Richard D, SD Proctor. Feeding History and Obese-Prone Genotype Increase Survival of Rats Exposed to a Challenge of Food Restriction and Wheel Running. Obesity. (Silver Spring). 2012 Sep20(9):1787-95. (IF=3.53) PMID: 22016097

60) Axelsen LN, Keung W, Pedersen HD, Meier E, Riber D, Kjølbye AL, Petersen JS, Proctor SD, Holstein-Rathlou NH, and Lopaschuk GD. Glucagon and a glucagon-GLP-1 dual-agonist increases cardiac performance with different metabolic effects in insulin-resistant hearts. British Journal Pharmacology. 2012 Apr;165(8):2736-48. (IF=4.92)PMID:  22014161

61) Borthwick F, Warnakula S, Mangat R, Uwiera RR, Russell JC, Kelly SE, Lee CY, Hryshko L, Mamo JCL, Rye KA, Lopaschuk GD and Proctor SD. Apo-A1 infusion reduces arterial cholesterol and myocardial lesions in a rat model of cardiac dysfunction and insulin resistance. Atherosclerosis. 2012:Jun:222(2):402-8. (IF-3.79) PMID: 22483015

62) Pradiollo, J, Denes, A, Greenhalgh A, Herve B, Drake C, McColl B, Barton E, Proctor SD, Russell J, Rothwell N, Allan S. Delayed Administration of Interleukin-1Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Co-Morbid Rats. Journal of Cerebral Blood Flow & Metabolism. 2012 Sep;32(9):1810-9. (IF=5.0). PMID: 22781338 

63) Wang Y, Jacome-Sosa M, Ruth MR, Yu HM, Goruk SD, Shen J, Reaney MJ, Scott SL, Dugan MER, Anderson HD, Field CJ, Proctor SD and Vine DF. The intestinal bioavailability of vaccenic acid and activation of peroxisome proliferator-activated receptor α and -γ rodent model of dyslipidemia and the metabolic syndrome. Molecular Nutrition and Food Research. 2012;Aug;56(8):1234-46. (IF=4.3).   PMID: 22714958

64) Quiroga A, Li L, T Köfeler H, Trötzmüller M, Nelson R, Proctor SD, Köfeler H, Lehner R. Deficiency of Carboxylesterase 1/Esterase-x in Mice Results in Obesity, Hepatic Steatosis and Hyperlipidemia. Hepatology. 2012 Dec;56(6):2188-98.  (IF=12).   PMID: 22806626

65) Mangat R, Warnakula S, Borthwick F, Hassanali Z, Uwiera RRE, Russell JC, Cheeseman CI, Vine DF and Proctor SD. Arterial retention of remnant lipoproteins ex-vivo is increased during insulin resistance due to increased arterial biglycan and production of cholesterol-rich atherogenic particles, that can be improved by ezetimibe in the JCR:LA-cp rat. Journal of the American Heart Association (open access).  2012 Oct;1(5):e003434. doi: 10.1161/JAHA.112.003434. Epub 2012 Oct 25.  PMID: 23316299

66) Aukema H, Lu J, Borthwick F, and Proctor SD. Dietary fish oil reduces glomerular injury and improves elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome. British Journal of Nutrition. 2013 Jul 14;110(1):11-9. (IF=3.45).  PMID: 23151363

67) Wang Y, Pendlebury C, Nzekwu MMU, Maximova K, Vine DF, Jetha MM, Ball GDC, Proctor SD. Elevated remnant lipoproteins may increase subclinical CVD risk in obese pre-pubertal children: A Canadian case control study. Pediatr Obes. 2013 Oct;8(5):376-84.  PMID: 23239597

68) Diané A, Pierce DW, Borthwick F, Jacob R, Nelson R, Heth DC, Russell JC, Vine D, Proctor SD.  Differential Expression of Hypothalamic Metabolic Genes in Response to Short-Term Calorie Restriction in Young Obese- and Lean-prone JCR Rats.  Can J Diabetes. 2013 Apr;37 Suppl 2:S226. PMID: 24071111

69)  Diane A, Vine DF, Heth CD, Russell JC, Proctor SD, Pierce WD.   Prior caloric restriction increases survival of pre-pubertal obese- and PCOS-prone rats exposed to a challenge of time-limited feeding and physical activity.  Journal of Applied Physiology.  2013 May;114(9):1158-64. (IF=3.48) PMID: 23449943

70) Mapiye C, Aalhus JL, Turner TD, Rolland DC, Basarab JA, Baron VS, McAllister TA, Block HC, Uttaro B, Lopez-Campos O, Proctor SD, Dugan ME.  Effects of feeding flaxseed or sunflower-seed in high-forage diets on beef production, quality and fatty acid composition.  Meat Sci. 2013 Sep;95(1):98-109.  PMID:23669875

71) Diane A, Pierce WD, Russell JC, Heth CD, Vine DF, Richard D, Proctor SD. Down regulation of hypothalamic pro-opiomelanocortin (POMC) expression after weaning is associated with hyperphagia- induced obesity in JCR rats over-expressing neuropeptide Y. Br. J. Nutrition. 2013 Oct 7:1-9. PMID: 24094067 (IF=3.4)

72) Borthwick F, Mangat R, Warnakula S, Jacome-Sosa M, Vine DF and Proctor SD. Simvastatin treatment upregulates intestinal lipid secretion pathways in a rodent model of the metabolic syndrome. Atherosclerosis. 2014 232; pp. 141-148, PMID: 24401228 (IF=3.97)

73) Rajabi AA, Castro GS, da Silva RP, Nelson RC, Vannucchi H, Vine DF, Proctor SD, Field CJ, Curtis JM, Jacobs RL. Choline Supplementation Protects Against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet. Journal of Nutrition (Biochemistry). Journal of Nutrition. 2014 Mar;144(3):252-7. PMID: 24368431 (IF=4.59)

74) C. Mapiye, J. L. Aalhus, T. D. Turner, D. C. Rolland, J. A. Basarab, V. S. Baron, T. A. McAllister, H. C. Block, B. Uttaro, S. D. Proctor and M. E. R. Dugan. Types of Oilseed and Adipose Tissue Influence the Deposition and Metabolic Relationships of Fatty Acid Biohydrogenation Intermediates in Steers Fed a Grass Hay Diet. Lipids. 2014 Mar;49(3):275-86. PMID: 24399450 (IF=2.3)

75)Dromparis P, Sutendra G, Paulin R; Proctor SMichelakis ED, M. McMurtry MS. Pioglitazone inhibits HIF-1α dependent angiogenesis in rats by paracrine and direct effects on endothelial cells. J Mol Med (2014) 92:497–507. (IF=4.8)  PMID: 24408111

76) MM Jacome-Sosa, Y Wang, Borthwick F, Jacobs RL, Uwiera R, Nelson R, Reaney MJ, Shen J, Quiroga AD, Lehner R, Proctor SD.  Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation by remodeling adipose tissue in a rat model of NAFLD and the metabolic syndrome. Journal of Nutrition (Biochemistry). 2014 Volume 25, Issue 7, Pages 692-701. (IF=4.55). PMID: 24775093 (IF=4.59)

77) Mangat R and Proctor SD. Emerging pathways in the regulation of whole body cholesterol flux: therapeutic opportunities to target atherosclerosis? J Lipid Res. 2014 May;55(5):796-797. (IF=4.73) PMID: 24670991 (Invited Commentary). 

78) Diane A, Vine DF, Russell JC,  Heth CD, Pierce WD, and Proctor SD. Interrelationship of CB1R and OBR pathways in regulation of metabolic, neuroendocrine and behavioral responses to food restriction and voluntary wheel running. J. Applied Physiology. 2014 Jun 15;117(2):97-104. PMID: 24903921. (IF=3.4)

79)Hutcheson R, Chaplin J, Hutcheson B, Gebb S, Jadhav R, Smith E, Russell JC, Proctor SD, Rocic P. Excessive, miR-21-mediated vascular smooth muscle proliferation in impaired coronary collateral growth in metabolic syndrome. FASEB Journal 2014 28(9) pg 4088-4099  (IF=5.8)

80) Vine DF, Wang Y, Shi D, Proctor SD.  Insulin and testosterone are associated with elevated intestinal secretion of lipids and lipoproteins in a rodent model of the metabolic and polycystic ovary syndrome.  Journal Diabetes and Metabolism.  2014 5(391): 2155-6156, Open Access

81) Cletos Mapiye, Jennifer L Aalhus, Payam Vahmani, Rolland C David, McAllister A Timothy, Block C Hushton, Uttaro Bethany, Spencer D Proctor and Michael E R Dugan. Improving beef hamburger quality and fatty acid profiles through dietary manipulation and exploitation of fat depot heterogeneity. Journal of Animal Science and Biotechnology. 2014, 5:54. (open access).

82) Natasha Fillmore, Wendy Keung, Sandra E Kelly, Spencer D Proctor, Gary D Lopaschuk, and John R Ussher. Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat. Experimental Physiology. 2015 Jun 1;100(6):730-41.  PMID: 25786668

83) Rebecca Hutcheson, Russell Terry, Brenda Hutcheson, Rashmi Jadhav, Jennifer Chaplin, Erika Smith, Robert Barrington, Spencer Proctor, and Petra Rocic. miR-21-mediated decreased neutrophil apoptosis is a determinant of impaired coronary collateral growth in metabolic syndrome. American Journal of Physiology- Heart and Circulatory Physiology.  2015 Jun 1;308(11):H1323-35.  PMID: 25840830

84) da Silva RP, Karen B Kelly KB; Lewis E, Leonard KA, Goruk S, Curtis JM, Vine DF; Proctor SD, Field CJ and Jacobs R. Choline deficiency impairs intestinal lipid metabolism in the lactating rat. Journal of Nutrition (Biochemistry). 2015 May 29.doi: 10.1016/j.jnutbio.2015.04.015. [Epub ahead of print].  PMID: 26092371

85) Diane A, Kupreeva M, Borthwick F, Proctor SD, Pierce DW and Vine DF. Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model. Endocrinology 2015 Sep;226(3):193-206. PMID: 26187902.  (IF=3.718)

86) Diane A, Pierce DW, Mangat R, Borthwick F, Nelson R, Russell J, Heth C, Jacobs R, Vine DF, and Proctor SD.  Differential Expression of Hypothalamic Metabolic and Inflammatory Genes in Response to Short-Term Calorie Restriction in Juvenile Obese- and Lean-prone JCR Rats.  Nutrition & Diabetes.  2015 Aug 24;5:e178. Open Access. PMID: 26302065.  (IF=2.654) 2)

87) Suresh C Bairwa, Venkatesh Rajapurohitam, Xiaohong Tracey Gan, Rabban Mangat, Spencer D Proctor, Morris Karmazyn. Cardiomyocyte Antihypertrophic Effect of Adipocyte Tissue Conditioned Medium from Rats and its Abrogation by Obesity is Mediated by the Leptin to Adiponectin Ratio. PLoS One. 2016 Jan 5;11(1):e0145992. doi: 10.1371/journal.pone.0145992.

88) Wang X, Gupta J, Kerslake M, Rayat G, Proctor SD and Chan CB. Trans-11 Vaccenic Acid Improves Insulin Secretion in Models of Type 2 Diabetes In Vivo and In Vitro.Molecular Nutrition & Food Research. 2016 Apr;60(4):846-57.PMID:27061233.(IF=4.6)

89) Uwiera RRE, Mangat R, Kelly SE, Uwiera TC and Proctor SD. Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs. Journal of Visualized Experiments. 2016 Mar 5;(109). PMID:27023826

90) Jacome-Sosa MM, Vacca C, Mangat R, Diane A, Nelson RC, Reaney MJ, Shen J, Curtis JM, Vine DF, Field C, Igarashi M, Piomelli D, Banni S and Proctor SD. Vaccenic acid suppresses intestinal inflammation by increasing the endocannabinoid anandamide and non-cannabinoid signaling molecules in a rat model of the metabolic syndrome. Journal of Lipid Research. 2016 Apr;57(4):638-49. PMID: 26891736 (IF=4.4)

91) Diane A, Borthwick F, Mapiye C, Vahamani P, David RC, Vine DF, Dugan M, Proctor S. Feeding beef fat enriched with polyunsaturated fatty acid biohydrogenation products improves insulin sensitivity in insulin resistant JCR:LA-cp rats. Lipids.2016 Jul;51(7):821-31.PMID:27072368

92) Vahmani, P., D.C. Rolland, T.A. McAllister, H.C. Block, S.D. Proctor, L. L. Guan, N. Prieto, J.L. Aalhus, and M.E.R. Dugan. Feeding steers hay with extruded flaxseed together or sequentially has a 1 profound effect on erythrocyte trans 11-18:1 (vaccenic acid). Canadian Journal of Animal Science, 2016 Aug;96:299-301.

93)
Wilke MS, Maximova K, Henderson M, Levy E, Paradis G, O'Loughlin J, Tremblay A, Proctor SD. Adiposity in Children and CVD risk: ApoB48 has a stronger association with central fat than classic lipid markers. J Clin Endocrinol Metab. 2016 Jul;101(7):2915-2922.PMID: 27163356 (IF=6.2)

94) Singh, V, Willing B, Proctor SD. Koch's postulates, microbial dysbiosis and inflammatory bowel disease. Clinical Microbiology and Infection. 2016 Jul;22(7):594-9. PMID:27179648 (IF=5.2).

95) Diane A, Borthwick F, Wu S, Lee J, Shipley PR, Brown PN, Dickinson TA, Croft KD, Vine DF and Proctor SD. Hypolipidemic and cardioprotective benefits of a novel Fireberry Hawthorn fruit extract in the JCR:LA-cp rodent model of dyslipidemia and cardiac dysfunction. PMID:27538786.  Food and Function. 2016 Sep 14;7(9):3943-52.

96) Diane A, Pierce D, Kelly S, Sokolik S, Borthwick F, Jacome-Sosa M, Mangat R, Pradillo MJ, McRae AS, Ruth MR, Field CJ, Hutcheon R, Rocic P, Russell JC, Vine DF, Proctor SD.  Mechanisms of Co-Morbidities Associate with The Metabolic Syndrome:  Insights From The JCR:LA-cp Corpulent Rat Strain.  Frontiers.  2016 Oct. 10;3:44.  PMID:  27777929(IF=Open Access)