Research / Dr. Donna Vine / Publications


Scientific Publications: Internationally Referred


Trainees and Staff Underlined

*authors equal senior authors

  1. Mamo J.C.L. Elsegood C., Yu K., Smith D., Vine D.F., Gennat H., Vovedin M. and Proctor S.D. (1997) Is atherosclerosis exclusively a post-prandial phenomenon? Clinical experimental Pharmacology and Physiology; 24:288-293.
  2. Vine DF, Croft KD, Beilin LJ and Mamo JCL. (1997) Absorption of Dietary Cholesterol Oxidation Products and Incorporation into Lymph Chylomicrons. Lipids; 32(8)887-893.
  3. Vine D,, MamoJ.C.L.,Beilin L.J., Mori T. and Croft K.D. (1998) Dietary oxysterols are incorporated in plasma triglyceride rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits. Journal of Lipid Research, 39:1995-2004.
  4. Vine D.F, Croft K.D. ,Beilin L.J. and Mamo J.C.L. The Effect of Dietary Cholesterol Oxidation Products on the Plasma Clearance of Chylomicrons in the Rat.  Lipids.   2002 May;37(5):455-62.
  5. Vine D.F, S. A. Charman, C.J.H. Porter. (2002) Effect of dietary fatty acids on the permeability characteristics of the intestinal BBM in vitro using markers of passive and active transport. Journal Pharmaceutics and Pharmacology;54:809-19.
  6. Proctor S.D.,Vine D.F. and Mamo J.C. (2002) Arterial Retention of ApoB48 and ApoB100-containing Lipoproteins in Atherogenesis. Current Opinion in Lipidology, Vol 13; Issue 5, Pg 461-470 (Front Cover Feature).
  7. James AP, Pal S, Gennat HC, Vine DF, Mamo JC. (2003) The incorporation and metabolism of amyloid-beta into chylomicron-like lipid emulsions. J Alzheimers Dis. Jun;5(3):179-88.
  8. Proctor SD, Vine DF, Mamo JC. (2004) Arterial permeability and efflux of apolipoprotein B-containing lipoproteins assessed by in situ perfusion and three-dimensional quantitative confocal microscopy. Arterioscler Thromb Vasc Biol. Nov;24(11):2162-7. (IF= 6.858)
  9. Oddy WH, Pal S, Kusel MM, Vine DF, de Klerk NH, Hartmann P, Halt P, Sly P, Burton P, Stanley F and Landau LI (2006). Atopy, eczema and breast milk fatty acids in a high-risk cohort of children followed from birth to 5 yr. Pediatr Allergy Immunol. Feb;17(1):4-10.
  10. Mangat R, Vine DF and Proctor SD (2007). Chylomicron and apoB48 metabolism in the JCR:LA corpulent rat, a model for the metabolic syndrome. Biochemical Society Transactions Jun;35(Pt 3):477-81. (IF=3.447).
  11.  Vine DF, Takechi R, Russell JC and Proctor SD (2007). Impaired postprandial apolipoprotein – B48 insulin-resistant JCR:LA-cp rat model.  Increased atherogenicity for the metabolic syndrome.  Atherosclerosis 190 (2007) 282-290.
  12. Proctor SD, Kelly S, Vine DF and Russell JC (2007). Metabolic effects of a novel silicate inositol complex of the nitric oxide precursor arginine in the obese, insulin resistant JCR:LA-cp rat. Metabolism. Oct;56(10):1318-25.
  13. Proctor SD, Vine DF, Botham K, Mamo JCL and Cabezas MC (2008). Intestinal post-prandial chylomicrons: State of the Union between liver, gut and dyslipidemia? Future Lipidology. 3(5):473-480.
  14. Vine DF, Glimm DR, Proctor SD (2008). Intestinal Lipid Transport and Chylomicron Production: Possible Links to Exacerbated Atherogenesis in a Rodent Model of the Metabolic Syndrome. Atherosclerosis Suppl. 9(2):69-76. (IF=4.287)
  15. Wang Y, Lu J, Ruth MR, Goruk SD, Reaney M, Glimm D, Vine DF, Field CJ and Proctor SD (2008). Trans-11 vaccenic acid dietary supplementation induces hypolipidemic effects in an animal model of dyslipidemia and the metabolic syndrome. Journal of Nutrition. Vol. 138, No. 11, 2117-2122.  (IF=4.0)
  16. Shi D, Dyck M, Uwiera R, Russell J, Proctor S, Vine DF (2009). A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic and Polycystic Ovary Syndrome. Endocrinology Vol. 150, No. 9 4425-4436, Sep 2009. (IF=5.2).
  17. Field CJ, Hosea-Blewett H, Proctor SD and Vine DF. Human health benefits of vaccenic acid. Applied Physiology, Nutrition and Metabolism. 2009.  Vol. 34, Number 5, 979-991.
  18. Russell JC, Kelly SE, Vine DF and Proctor SD. Irbesartan-mediated reduction of renal and cardiac damage in insulin resistant  JCR:LA-cp rats. British Journal of Pharmacology. 2009.  Vol. 158, Issue 6, Pages 1588-1596.  (IF=4.9)
  19. Wang Y, Lu J, Ruth MR, Goruk SD, Reaney M, Glimm D, Vine DF, Field CJ and Proctor SD. Trans-11 vaccenic acid reduces hepatic lipogenesis and chylomicron secretion in the JCR:LA-cp rat. Journal of Nutrition. Vol. 139, No.11, 2049-2054. Nov. 2009. (IF=4.0)
  20. Ruth MR, Wang Y, Yu HM, Goruk S, Reaney MJ, Proctor SD,  Vine DF,  and Field CJ.  Vaccenic and Elaidic Acid Modify Plasma and Splenocyte Membrane Phospholipids and Mitogen-Stimulated Cytokine Production in Obese Insulin Resistant JCR: LA-cp Rats.  Nutrients Journal.  2010.  Feb;2(2):181-97
  21. Hassanali Z, Ametaj B, Field CJ, Vine DF and Proctor SD. Dietary supplementation with n-3 polyunsaturated fatty acids reduces weight gain and improves post-prandial lipemia and the associated inflammatory response in the obese JCR:LA-cp rodent. Diabetes Obesity and Metabolism.  2010.  Volume 12, Issue 2, Pages 139 – 147.  (IF=4.2)
  22. Mangat R, Warnakula S, Wang Y, Russell JC, Uwiera R and Vine DF and Proctor SD.  Model of Intestinal Chylomicron Over-production and Ezetimibe Treatment: Impact on the Retention of Cholesterol in Arterial Vessels.  Atherosclerosis Supplements.  2010 Jun;11(1):17-24. 
  23. Jacome-Sosa M, Lu J, Wang Y, Ruth MR, Wright DC, Reaney MJ, Shene J, Field CJ, Vine DF and Proctor SD. Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat.  Nutrition & Metabolism.  Nutr Metab (Lond). 2010 Jul 16;7:60.
  24. Wang Y, Jacome-Sosa M, Vine DF and Proctor SD.  Beneficial effects of vaccenic acid on postprandial lipid metabolism and dyslipidemia: Impact of natural trans-fats to improve CVD risk.  Lipid Technology. Vol. 22 No. 5, Pages 103-106. May 2010.
  25. Russell JC, Kelly SE, Diane A, Wang Y, Mangat R, Novak S, Vine DF*, Proctor SD*.  Rimonabant-mediated changes in intestinal lipid metabolism and improved vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome.  AJP Gastro and Liver Physiol.  2010 Aug;299(2):G507-16.
  26. Mangat R, Vine DF, Forbes JM, Cooper ME, Mamo JCL and Proctor SD.  Increased risk of cardiovascular disease in type 1 diabetes: arterial exposure to remnant lipoproteins leads to enhanced deposition of cholesterol and binding to glycated extracellular matrix proteoglycans.  Diabetic Medicine.  2011 Jan;28(1):61-72
  27. Lu J, Borthwick F, Hassanali Z, Wang Y, Mangat R, Shi D, Jaeschke A, Russell J, Field CJ, Proctor SD * and Vine DF *.  Chronic dietary n-3 PUFA intervention improves dyslipidemia and subsequent cardiovascular complications in the JCR:LA-cp rat model of the metabolic syndrome.  British Journal of Nutrition (2011), volume 105, issue 11, pp. 1572-1582 (IF=3.4).
  28. Wang Y, Jacome-Sosa M, Ruth MR, Goruk SD, Shen J, Reaney MJ, Scott SL, Dugan MER, Anderson HD, Field CJ, Proctor SD and Vine DV.  The intestinal bioavailability of vaccenic acid and activation of peroxisome proliferator-activated receptor α and -γ rodent model of dyslipidemia and the metabolic syndrome. Molecular Nutrition and Food Research.  2012 Aug;56(8)1234-46.  (IF=4.3)
  29. Shi D and Vine DF.  Animal models of polycystic ovary syndrome:  a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk.  Reproductive Biology.  2012 Jul;98(1):185-93.   
  30. Vine DF, Bakovic M. Mechanisms of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) deficient mice.  Journal of Lipid Research.  2012 Sep;53(9):1811-22.
  31. Mangat R, Warnakula S, Borthwick F, Hassanali Z, Uwiera R, Russell JC, Cheeseman CI, Vine DF and Proctor SD. Arterial retention of remnant lipoproteins ex-vivo is increased during insulin resistance due to increased arterial biglycan and production of cholesterol-rich atherogenic particles, that can be improved by ezetimibe in the JCR:LA-cp rat. Journal of the American Heart Association.  2012;1(5):e003434 doi: 10.1161/JAHA.112.003434. Epub 2012 Oct PMID:23316299.
  32. .Mager DR, Mazurak V, Rodrigues-Dimitrescu C, Vine DF, Jetha M, Ball G, Yap J.  A meal high in saturated fat evokes postprandial dyslipemia, hyperinsulinemia, and altered lipoprotein expression in obese children with and without nonalcoholic fatty liver disease.  Journal of Parenteral and Enteral Nutrition.  2013 Jul;37(4):517-28. PMID:  23223552.
  33. Diane A, Vine DF, Heth CD, Russell JC, Proctor SD, Pierce WD. Prior caloric restriction increases survival of pre-pubertal obese- and PCOS-prone rats exposed to a challenge of time-limited feeding and physical activity.  Journal of Applied Physiology. 2013 May;114(9):1158-64. PMID: 23449943
  34. Wang Y, Pendlebury C, Nzekwu MMU, Maximova K, Vine DF, Jetha MM, Ball GDC and Proctor SD. Elevated remnant lipoproteins may increase subclinical CVD risk in obese pre-pubertal children: A Canadian case control study.  Pediatr Obes. 2013 Oct;8(5):376-84. PMID: 23239597
  35. Vine DF, Wang Y, Shi D, Proctor SD. Insulin and testosterone are associated with elevated intestinal secretion of lipids and lipoproteins in a rodent model of the metabolic and polycystic ovary syndrome. Journal Diabetes and Metabolism.  2014:5(6):391-399(5): 391-99.
  36. Leblanc S, Battista MC, Noll C, Hallberg A, Gallo-Payet N, Carpentier AC, Vine DF, Baillargeon JP.(2014). Insulin and testosterone are associated with elevated intestinal secretion of lipids and lipoproteins in a rodent model of the metabolic and polycystic ovary syndrome.  Endocrinology. 155(9): 3684-93.
  37. Diane A, Pierce WD, Russell JC, Heth CD, Vine DF, Richard D, Proctor SD. Down regulation of hypothalamic pro-opiomelanocortin (POMC) expression after weaning is associated with hyperphagia- induced obesity in JCR rats over-expressing neuropeptide Y.  Br. J. Nutrition. 2013 Oct 7:1-9. PMID: 24094067 (IF=3.4)
  38. Borthwick F, Mangat R, Warnakula S, Jacome-Sosa M, Vine DF and Proctor SD. Simvastatin treatment upregulates intestinal lipid secretion pathways in a rodent model of the metabolic syndrome. Atherosclerosis. 2014 232; pp. 141-148, PMID:24401228 (IF=3.97)
  39. Rajabi AA, Castro GS, da Silva RP, Nelson RC, Vannucchi H, Vine DF, Proctor SD, Field CJ, Curtis JM, Jacobs RL. Choline Supplementation Protects Against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet. Journal of Nutrition (Biochemistry). Journal of Nutrition. 2014 Mar;144(3):252-7. PMID: 24368431 (IF=4.59)
  40. Diane A, Vine DF, Russell JC,  Heth CD, Pierce WD, and Proctor SD. Interrelationship of CB1R and OBR pathways in regulation of metabolic, neuroendocrine and behavioral responses to food restriction and voluntary wheel running. J. Applied Physiology. 2014 Jun 15;117(2):97-104. PMID: 24903921. (IF=3.4)
  41. Vine DF, Wang F, Jetha MM, Proctor SD, Ball G.  Elevated Non-Fasting and Fasting ApoB-Lipoprotein Metabolism in Obese Adolescents with PCOS and Exacerbated Cardiovascular Disease Risk.  Endocrine Reviews. 2014 Jun 22;35(3):OR15. 
  42. Zhang J, Field CJ, Vine DF, Chen L.  Intestinal Uptake and Transport of Vitamin B12-loaded Soy Protein Nanoparticles. Pharmaceutical Research.  2015 April;4(32)1288-1303.
  43. da Silva RP, Karen B Kelly KB; Lewis E, Leonard KA, Goruk S, Curtis JM, Vine DF, Proctor SD, Field CJ and Jacobs R. Choline deficiency impairs intestinal lipid metabolism in the lactating rat. Journal of Nutritional Biochemistry. 2015 Oct;26(10):1077-1083. PMID: 26092371.
  44. Diane A, Pierce W, Mangat R, Borthwick F, Nelson R, Russell J, Heth C, Jacobs R, Vine DF, and Proctor SD.  Differential Expression of Hypothalamic Metabolic and Inflammatory Genes in Response to Short-Term Calorie Restriction in Juvenile Obese- and Lean-prone JCR Rats.  Nutrition & Diabetes.  2015 Aug 24;5:e178. Open Access. PMID: 26302065.
  45. Diane A, Kupreeva M, Borthwick F, Proctor SD, Pierce WD, Vine DF.  Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model.  J Endocrinol. 2015 Sep;226(3):193-206.  PMID: 26187902
  46. Jacome-Sosa MM, Vacca C, Mangat R, Diane A, Nelson RC, Reaney MJ, Shen J, Curtis JM, Vine DF, Field C, Igarashi M, Piomelli D, Banni S and Proctor SD. Vaccenic acid suppresses intestinal inflammation by increasing the endocannabinoid anandamide and non-cannabinoid signaling molecules in a rat model of the metabolic syndrome. Journal of Lipid Research. 2016 Apr;57(4):638-49. PMID: 26891736 
  47. Diane A, Borthwick F, Mapiye C, Vahamani P, David RC, Vine DF, Dugan M, Proctor S.(2015). Beef fat enriched with PUFA biohydregenation products improves insulin sensitivity in insulin resistant JCR:LA-cp rats. Lipids. 2016 Jul;51(7):821-31.  PMID:  27072368
  48. Jacome-Sosa MM, Vacca C, Diane A, Reaney MJ, Shen J, Curtis J, Vine DF, Field C, Banni S and Proctor SD. Trans-11 vaccenic acid exerts tissue specific regulation of endocannabinoids in a rodent model of metabolic syndrome (the JCR:LA-cp rat). Journal of Lipid Research. 2016 Apr;57(4):638-49. PMID: 26891736
  49. Diane A, Borthwick F, Mapiye C, Vahamani P, David RC, Vine DF, Dugan M, Proctor S. Feeding beef fat enriched with polyunsaturated fatty acid biohydrogenation products improves insulin sensitivity in insulin resistant JCR:LA-cp rats. Lipids.  2016 Jul;51(7):821-31.  PMID:  27072368
  50. Diane A, Pierce D, Kelly S, Sokolik S, Borthwick F, Jacome-Sosa M, Mangat R, Pradillo MJ, McRae AS, Ruth MR, Field CJ, Hutcheon R, Rocic P, Russell JC, Vine DF, Proctor SD.  Mechanisms of Co-Morbidities Associate with The Metabolic Syndrome:  Insights From The JCR:LA-cp Corpulent Rat Strain.  Frontiers.  2016 Oct. 10;3:44.  PMID:  27777929.  (IF=Open Access)
  51. Abdoulaye Diane, Faye Borthwick, Sheng Wu, Jeanette Lee, Paula N Brown, Timothy A Dickinson, Kevin D Croft,  Donna F Vine,  Spencer D Proctor.   Hypolipidemic and cardioprotective benefits of a novel fireberry hawthorn fruit extract in the JCR:LA-cp rodent model of dyslipidemia and cardiac dysfunction.  Food and Function. 2016 Sep 14;7(9):3943-52.
  52. Lim DW, Diané A, Muto M, Vine DF, Nation PN, Wizzard PR, Sigalet DL, Bigam DL, Pencharz PB, Turner JM, Wales PW. Differential Effects on Intestinal Adaptation Following Exogenous Glucagon-Like Peptide 2 Therapy With and Without Enteral Nutrition in Neonatal Short Bowel Syndrome. JPEN J Parenter Enteral Nutr. 2017 Feb;41(2):156-170.  PMID: 27660290
  53. Mangat R, Borthwick F, Haase T, Jacome-Sosa MM, Nelson R, Kontush A, Vine DV, Proctor SD.  Intestinal lymphatic HDL miR-223 is involved in HDL biogenesis that is impaired during insulin resistance and is restored with Niacin. The FASEB Journal.  In Press. 
  54. Vine DF, Wang F, Jetha M, Ball G, Proctor SD. Impaired ApoB-Lipoprotein and Triglyceride Metabolism in Obese Adolescents with Polycystic Ovary Syndrome. Journal Clinical Endocrinology and Metabolism. 2017 Mar 1;102(3):970-982. PMID:27997268 (IF=6.2)
  55. Jacqueline A Krysa, Spencer D Proctor, Donna F Vine. Metabolic and Dietary Modulation of PCSK9; Effects on CardiometaboRisk Factors.  Journal of Nutrition. 2017 Apr;147(4):473-481. PMID:28179493  (IF-4.145). 
  56. Ooi TC, Krysa J, Chaker S, Abujrad H, Mayne J, Henry K, Cousins M, Raymond A, Favreau C, Taljaard M, Chrétien M, Mbikay M, Proctor SD, Vine DF. The Effect of PCSK9 Loss-of-Function Variants on the Postprandial Lipid and ApoB-Lipoprotein Response. J Clin Endocrinol Metab. 2017 Sep 1;102(9):3452-3460. PMID: 28673045. (IF=5.455). 
  57. Wang Y, Shi D, Diane A. Russell JC, Proctor SD, Vine DF. Postprandial dyslipidemia and intestinal lipoprotein overproduction in a rodent model of polycystic ovary syndrome. Journal of Diabetes and Metabolism.  Under Revision
  58. Mangat R, Ullrich T, Borthwick F, Jacome M, Kelly SE, Vine DF and Proctor SD. Insulin Resistance causes simultaneous overproduction of atherogenic ApoB lipoproteins and under production of anti-atherogenic ApoAI lipoproteins from the intestine, that can be reverse by Niacin in JCR:LA-cp rats. Under Second Revision FASEB Journal
  59. Ye Wang and Donna F. Vine. (2015). Modulation of Dietary Lipids and Effects on Cardiometabolic and Endocrine-Reproductive Aberrations in Polycystic Ovary Syndrome. Advances in Nutrition.  Submitted
  60. Krysa J, Vine D, Beilin L, Burrow S, Huan R-C, Mori T, Proctor S.  ApoB48-Lipoprotein Remnants Are Associated with Increased Cardiometabolic Risk in Adolescents. JCEM.  Submitted
  61. Diane A, Kupreeva M, Proctor SD, Vine DF.  Metformin-flutamide and exercise treatment differentially effect plasma triglycerides, apoB-liporoteins and endocrine outcomes in a rodent model of Metabolic Syndrome and PCOS. Endocrinology. Submitted
  62. Lim DW, Levesque CL, Vine DF, Muto M, Koepke JR, Nation PN, Wizzsard PR, Li J, Bigam DL, Brubaker PL, Turner J. Synergy of glucagon-like peptide-2 and epidermal growth factor co-administration on intestinal adaptation in neonatal piglets with short bowel syndrome.  American Journal of Physiology-Gastrointestinal and Liver Physiology (under review).
  63. Kupreeva M, Diane A, Proctor S, Vine DF.  Metformin and Flutamide Differentially Modulate Insulin-Glucose, Lipid and Apo-B Lipoprotein Metabolism, and Reproductive-Endocrine Function in a PCOS-prone rodent model. Am J Physiol: Endocrinol and Metab.  Submitted.