Research / Dr. René Jacobs / Publications

Publications

Refereed Papers- Published

  1. Lewis ED, Goruk S, Richard C, Dellschaft NS, Curtis JM, Jacobs RL, Field CJ. Feeding a diet devoid of choline to lactating rodents restricts growth and lymphocyte development in offspring. Br J Nutr. 2016 Sep;116(6):1001-12.
  2. Kelly KB, Kennelly JP, Ordonez M, Nelson R, Leonard K, Stabler S, Gomez-Muñoz A, Field CJ, Jacobs RL Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats.Nutrients. 2016 Sep 23;8(10).
  3. Hetherington AM, Sawyez CG, Sutherland BG, Robson DL, Arya R, Kelly K, Jacobs RL, Borradaile NM. Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice. Physiol Rep. 2016 Sep;4(17).
  4. van der Veen J, Lingrell S, Gao X, Quiroga AD, Lehner R, Vance DE, Jacobs RL. Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase (PEMT) deficient mice.  American Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G526-38.
  5. Lewis ED, Goruk S, Dellschaft NS, Jacobs RL, Curtis JM, Field CJ.  The form of choline in the maternal diet affects immune development in the suckled rat offspring. Journal of Nutrition 2016 Apr;146(4):823-30.
  6. Tasseva G, van der Veen J, Lingrell S, Jacobs RL, Vance DE, Vance JE.Lack of Phosphatidylethanolamine N-Methyltransferase in Mice Does Not Promote Fatty Acid Oxidation in Skeletal Muscle. Biochim Biophys Acta-MCBL. 2016 Feb;1861(2):119-29.
  7. Stamatikos AD, da Silva RP, Lewis JT, Douglas DN, Kneteman NM, Jacobs RL, Paton CM. Tissue-specific effects of dietary carbohydrates and obesity on ChREBPα and ChREBPβ expression. Lipids. 2016 Jan;51(1):95-104.
  8. Richard C, Lewis ED, Zhao Y-Y, Asomaning J, Jacobs RL, Field CJ, Curtis JM. Measurement of the total choline content in 48 commercial dairy products or dairy alternatives.  Journal of Food Composition and Analysis. 2016 45, pp.1-8.
  9. Tasseva G, van der Veen J*, Lingrell S*, Jacobs RL, Vance DE, Vance JE. (2015) Lack of Phosphatidylethanolamine N-Methyltransferase in Mice Does Not Promote Fatty Acid Oxidation in Skeletal Muscle. BBA-Molecular and Cell Biology of Lipids 1861(2):119-29.
  10. Lewis E*, Field CJ, Jacobs RL. Should the forms of dietary choline also be considered when estimating dietary intake and the implication for health?  Lipid Technology. 27 (10):227-230.
  11.  Gao X*, van der Veen JN*, Vance JE, Thiesen A, Vance DE, Jacobs RL. Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress. Biochim Biophys Acta- Molecular Basis of Disease. 2015 Dec;1852(12):2689-99.
  12. Gao X*, van der Veen JN*, Fernandez-Patron C, Vance JE, Vance DE, Jacobs RL. (2015) Insufficient glucose supply is linked to hypothermia upon cold exposure in mice lacking phosphatidylethanolamine N-methyltransferase. J Lipid Res. 56 (9);1701-10.
  13. Diane A, Pierce W, Mangat R, Borthwick R, Nelson R*, Russell R, Heth C, Jacobs R, Vine D, and Proctor S. (2015) Differential Expression of Hypothalamic Metabolic and Inflammatory Genes in Response to Short-Term Calorie Restriction in Juvenile Obese- and Lean-prone JCR Rats. Nutrition and Diabetes.  2015 Aug 24;5:e178.
  14. Lewis E*, Zhao Y-Y, Richard C, Bruce H, Jacobs R, Field C, Curtis J (2015) Measurement of the abundance of choline and the distribution of choline-containing moieties in meat. International Journal of Food Sciences and Nutrition 66(7):743-8.
  15. da Silva RP*, Kelly KB*, Leonard KA*, Goruk S, Curtis J, Vine D, Proctor SP, Field CJ, Jacobs RL. (2015). Choline deficiency impairs intestinal lipid metabolism in the lactating rat. Journal of Nutritional Biochemistry. 26(10):1077-83.
  16. Bickert A, Ginkel C, Kol M, vom Dorp K, Jastrow H, Degen J, Jacobs RL, Vance DE, Winterhager E, Jiang X-C, Dörmann P, Somerharju P, Holthuis JCM and Willecke K. (2015). Ceramide phosphoethanolamine synthase SMSr is not a critical mediator of ceramide homeostasis in mice. Journal of Lipid Research. Apr;56(4):821-35.
  17. Dellschaft N, Ruth MR, Goruk S, Lewis E*, Richard C, Jacobs RL, Curtis JM, Field CJ. (2015). Choline is required in the diet of lactating dams to maintain maternal immune function. British Journal of Nutrition. British Journal of Nutrition. Jun 14;113(11):1723-31.
  18. Gao X*, van der Deen J, Lingrell S, Koonen DPY, Dyck JRB, Vance DE, Jacobs RL. (2015) Vagus nerve signals contribute to the resistance of phosphatidylethanolamine N-methyltransferase deficient mice to high fat diet-induced obesity. Journal of Hepatology 62(4):913-920.
  19. Gao X*, van der Veen J*, Hermansson M*, Ordonez M, Gomez-Muñoz A, Vance D and Jacobs RL. (2015). Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase deficient mice. BBA - Molecular and Cell Biology of Lipids. 1851(2):152-162.
  20. Deminice R1, da Silva RP, Lamarre SG, Kelly KB, Jacobs RL, Brosnan ME, Brosnan JT. Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism. Amino Acids. 2015 Apr;47(4):839-46.
  21. Jacome-Sosa MM, Borthwick F, Mangat R, Uwiera R, Reaney MJ, Shen J, Quiroga AD, Jacobs RL, Lehner R, Proctor SD. (2014) Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome. J Nutr Biochem. Jul;25(7):692-701.
  22. da Silva RP*, Kelly KB*, Leonard K*, Jacobs RL. (2014). Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation. BBA - Molecular and Cell Biology of Lipids. 1841(11): 1639-194.
  23. Fayyza F, Wang F, Jacobs RL, O'Connor DL, Bell R, Field C. (2014). Folate, vitamin B12 and vitamin B6 status in pregnant Albertan women. 2014 Appl. Physiol. Nutr. Metab. 39: 1402–1408
  24. Lewis E*, Subhan F, Bell R, McCargar L, Curtis J, Jacobs RL, Field C. (2014). Estimation of choline intake from 24 h dietary intake recalls and contribution of egg and milk consumption to intake among pregnant and lactating women in Alberta. British Journal OF Nutrition. 112(1): 112-121
  25. da Silva RP*, Kelly KB*, Al Rajabi A*, Jacobs RL. (2014). Novel Insights on Interactions between folate and lipid metabolism. Biofactors. 40(3): 277-283.
  26. Lewis E*, Kosik S, Zhao Y, Jacobs RL, Curtis J, Field C. (2014). Total choline and choline-containing moieties of commercially available pulses. Plant Foods for Human Nutrition. 69(2): 115-121.
  27. Sheedfar, F, Sung, M.M.Y., Aparicio-Vergara, M., Kloosterhuis, N.J., Miquilena-Colina, M.E., Vargas-Castrillón, J., Febbraio, M., Jacobs, R.L., de Bruin, A., Vinciguerra, M., García-Monzón, C., Hofker, M.H., Dyck, J.R.B., Koonen, D.P.Y. (2014). Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease. Aging. 6(4): 281-295.
  28. Rajabi A*, Castro GSF*, da Silva R*, Nelson R*, Kelly SE, Curtis J, Vine DF, Proctor SD and Jacobs RL. (2014). Choline Supplementation Protects Against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet. Journal of Nutrition. 144(3): 252-257.
  29. van der Veen JN, da Silva R, Lingrell S, Jacobs RL, Vance DE. The concentration of phosphatidylethanolamine in mitochondria can modulate ATP production and glucose metabolism in mice. 2014 Diabetes. 63: 2620-2630.
  30. Jacobs RL (Corresponding), van der Veen JN, Vance DE. Finding the Balance: The role of SAMe and phosphatidylcholine metabolism in development of non-alcoholic fatty liver disease. Hepatology. 2013 Hepatology (Baltimore, Md.). 58(4): 1207-1209.
  31. Erickson B, Paramadayalan, Ko KWS, Kelly K, King-Jones K, Jacobs RL, and Lehner R. Intracellular Hepatic Lipase Activity Attenuates Steatosis And VLDL Secretion Biochim Biophys Acta. 2013 Jun;1831(6):1113-23.
  32. Ziong Y, Zhao YY, Goruk S, Oilund K, Field CJ, Jacobs RL, Curtis JM.  Validation of a LC-­‐MS/MS method for the quantification of choline-­‐related compounds and phospholipids in foods and tissues. Journal of Chromatography. 2012 Dec 12;911:170-9.
  33. Wu G, Zhang L, Li T, Lopaschuk G, Jacobs RL, Vance DE. Choline Induces Glucose and Insulin Intolerance in Phosphatidylethanolamine N-Methyltransferase-Deficient Mice via Glucagon and its Receptor. J Biol Chem. 2013 Jan 11;288(2):837-47.
  34. Ling NJ, Zhu LF, Vance DE, Jacobs RL. Impaired phosphatidylcholine biosynthesis does not attenuate liver regeneration after 70% partial hepatectomy in hepatic CTP:phosphocholinecytidylyltransferase α-deficient mice. Canadian Journal of Physiology and Pharmacology. 2012 Oct;90(10):1403-12.
  35. Wu G, Zhang L, Li T, Lopaschuk G, Vance DE, Jacobs RL. Choline Deficiency attenuates body weight gain and improves glucose tolerance in ob/ob mice. Journal of Obesity. 2012 Article ID 319172, 7 pages.
  36. Yu Z, Thomson ELS, Liu J, Dennis JJ, Jacobs RL, Kaufman WR. Antimicrobial activity in the egg wax of the tick Amblyomma hebraeum (Acari: Ixodidae) is associated with free fatty acids C16:1 and C18:2. Exp Appl Acarol. 2012 DOI 10.1007/s10493-012-9586-1, 18 pages.
  37. Ling NJ, Chaba T, Zhu LF, Jacobs RL, Vance DE. Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survivability after 70% partial hepatectomy in mice. Hepatology. 2012 Apr;55(4):1094-102.
  38. Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall L, Vance DE, Hart AC, Naar AM.  Control of one-carbon genes by SERBP-1 links SAMe production, phosphatidylcholine biosynthesis, and hepatic lipogenesis. CELL. 2011 November 11, 147:1-13.
  39. Wiebe N, Padwal R, Field C, Marks S, Jacobs RL, Tonelli M. A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes. BMC Medicine 2011, 123:1-18.
  40. Kelly KB and Jacobs RL. Phospholipid Biosynthesis. AOCS Lipid Library. 2011 July 28,  9 pages.
  41. Deminice R, da Silva RP, Lamarre SG, Brown C,   Furey G, McCarter S, Jordao AA, Kelly KB, Jacobs RL, Brosnan ME, Brosnan JT. Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet. Journal of Nutrition. 2011 141: 1799-1804.
  42. Niebergall LJ, Jacobs RL, Chaba T, Vance DE. Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. Biochim Biophys Acta. 2011 1811:1177-85.
  43. Sung MM, Koonen DPY, Soltys CLM, Jacobs RL, Febbraio M and Dyck JRB Increased CD36 Expression in Middle-Aged Mice Contributes to Obesity-related Cardiac Hypertrophy in the Absence of Cardiac Dysfunction J Mol Med. 2011 May;89(5):459-69.
  44. Frier BC, Jacobs RL, and Wright DC. Fasting-Dependent Induction of Genes Involved in Fatty Acid Oxidation are Blunted with High Fat Feeding: The Role of p38 MAPK and PRC. American Journal of Physiology (American Journal of Physiology) Am J Physiol Regul Integr Comp Physiol. 2011 Feb;300(2):R212-21.
  45. Cole LK, Jacobs RL, Vance DE. Tamoxifen induces triacylglycerol accumulation in mouse liver by activation of fatty acid synthesis. Hepatology. 2010 Oct;52(4):1258-65.
  46. Jacobs RL, Zhao Y, Koonen DP, Sletten T, Su B, Lingrell S, Cao G, Peake DA, Kuo MS, Proctor SD, Kennedy BP, Dyck JR, Vance DE. Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J Biol Chem. 2010 July; 285(29):22403-22413.Epub 2010 May 7 .
  47. Koonen DP, Sung MM, Kao CK, Dolinsky VW, Koves TR, Ilkayeva O, Jacobs RL, Vance DE, Light PE, Muoio DM, Febbraio M, Dyck JR. Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-aged Mice to Diet-induced Insulin Resistance. Diabetes. 2010 Jun;59(6):1366-75. Epub 2010 Mar 18.
  48. Zhao Y, Su B, Jacobs RL, Kennedy BP, Francis GA, Waddington E, Brosnan JT, Vance JE, and  Vance DE. Lack of Phosphatidylethanolamine N-methyltransferase alters plasma VLDL and Attenuates Atherosclerosis in Mice Lacking LDL Receptors. Arterioscler Thromb Vasc Biol. 2009 Sept (9)1349-55.
  49. Jacobs RL, Lingrell S, Zhao Y, Francis GA, Vance DE. Hepatic CTP:phosphocholine cytidylyltransferase-α is a critical predictor of plasma HDL and VLDL. J Biol Chem. Jan 2008;283:2147–2155. Epub 2007 Nov 27.
  50. Vance DE, Li Z, Jacobs RL. Phosphatidylethanolamine N-Methyltransferase – Unexpected Roles in Animal Biochemistry and Physiology. J Biol Chem. 2007 Nov 16;282:33237-33241. Epub 2007 Sept 19.
  51. Koonen, DPY, Jacobs RL, Febbraio M, Young ME, Ong H, Vance DE, Dyck JRB. Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated with Diet-Induced Obesity. Diabetes. 2007; 56: 2863 -2871. Epub 2007 Aug 29.
  52. Jacobs RL, Lingrell S, Dyck JR, Vance DE. Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation. J Biol Chem. 2007 Feb 16;282(7):4516-23. Epub 2006 Dec 19.
  53. Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, Vance DE, Wagner C. Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr. 2007;85(1):19-25.
  54. Hartz CS, Nieman KM, Jacobs RL, Vance DE, Schalinske KL. Hepatic phosphatidylethanolamine N-methyltransferase expression is increased in diabetic rats. J Nutr. 2006;136(12):3005-9. 
  55. Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL.  Is it time to re-evaluate methyl balance in humans? Am J Clin Nutr. 2006;83(1):5-10. 
  56. Jacobs RL, Stead LM, Devlin C, Tabas I, Brosnan ME, Brosnan JT, Vance DE. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem. 2005;280(31):28299-305. Epub 2005 Jun 15.
  57. Jacobs RL, Devlin C, Tabas I, Vance DE. Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins. J Biol Chem. 2004;279(45):47402-10. Epub 2004 Aug 25.
  58. Stead LM, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism. Adv Enzyme Regul. 2004;44:321-33.
  59. Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol. 2004;51(2):405-13.
  60. Ratnam S, Maclean KN, Jacobs RL, Brosnan ME, Kraus JP and Brosnan JT. Hormonal Regulation of Cystathionine Beta-Synthase Expression. J Biol Chem. 2002;277(45):42912-8. Epub 2002 Aug 26.
  61. Jacobs RL, Stead LM, Brosnan ME, and Brosnan JT. Hyperhomocysteinemia in rats results in lowered plasma homocysteine and increased hepatic transsulfuration flux. J Biol Chem. 2001 (276):43740-43747.
  62. Stead LM, Au PT, Jacobs RL, Brosnan ME, and Brosnan JT. Methylation Demand and Homocysteine Metabolism: Effects of dietary provision and creatine and guanidinoacetate. Am. J. Physiol Endocrinol Metab. 2001(281):E1095-1100.
  63. Jacobs RL, Stead LM, Brosnan ME, and Brosnan JT. Plasma homocysteine is decreased in the hypothyroid rat. Can. J. Physiol. Pharmacol. 2000 (78):1-6.
  64. House JD, Jacobs RL, Stead LM, Brosnan ME, and Brosnan JT. Regulation of homocysteine metabolism. Advances in Enzyme Regulation. 1999 (39):69-91.
  65. Jacobs RL, House JD, Brosnan ME, and Brosnan JT. Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism. Diabetes.1998 (47):1967-70.