Dr. Abdoulaye Diane
Project: Research Associate, Nov. 2012 - 2013 & June 2014 - April 2017
Use of pre-clinical swine models (the Landrace and Ossabaw Strains) to validate the cardioprotective effects of ruminant trans fats during diabetes.
1. Study the role of the hypothalamic orexigenic neuropeptide Y (NPY) and anorexigenic neuropeptide pro-opiomelanocortin (POMC) pathways in the alteration of energy balance during obesity.
2. Test the adaptive hypothesis that an obese-prone genotype confers a fitness advantage when animals are challenged with food restriction and food-related locomotion (activity anorexia), and also try to provide the neurophysiological mechanisms underlying this connection.3. Test how specific nutrients modulate these neuropeptides.
Supervisor: Dr. Spencer Proctor